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The Occupational Safety and Health Administration (OSHA) is the most common regulation regarding occupational safety and health. OSHA is a federal agency established under the Occupational Safety and Health Act of 1970 with a focus on ensuring safe and healthy working conditions for workers by setting and enforcing standards and providing training, outreach, education, and assistance.

OSHA regulations cover a wide array of workplace safety and health topics, including exposure to hazardous chemicals, machinery safety, and various workplace practices designed to minimize accidents and injuries. Compliance with OSHA standards is mandatory for most employers in the United States, making it the primary regulatory framework governing occupational safety and health.

While other options serve important roles in labor laws and worker protections, they do not specifically target occupational safety and health as comprehensively as OSHA does. The Fair Labor Standards Act (FLSA) deals with wage and hour laws, whereas the Federal Insurance Contributions Act (FICA) pertains to payroll taxes for Social Security and Medicare. The Safe Work Environment Agency (SWEA) does not exist under U.S. federal law and is not a recognized regulatory agency for occupational health and safety. Thus, OSHA stands out as the most relevant and widely recognized legislation in this context.